Opportunity Information: Apply for RFA CE 23 002
This funding opportunity, RFA CE 23 002, is a discretionary grant program from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), specifically the National Center for Injury Prevention and Control (NCIPC). It is structured as a Mentored Research Scientist Development Award (K01), meaning it is designed to help newer investigators build the skills, publication record, and scientific track record needed to become independent researchers. The core idea is to provide a sustained, closely supervised career development experience focused on substance use and overdose prevention, with an emphasis on generating research that can answer urgent public health questions tied to polydrug use and its connection to overdose risk.
The research focus is on understanding polydrug use: how it starts (initiation), how it continues (use), and how it worsens (escalation). Applicants are expected to propose a clearly defined research project that identifies and explains risk factors and protective factors that shape polydrug patterns. The CDC notes that this can include co-use of opioids, stimulants, and/or cannabis, but the scope is not limited to those substances as long as the work is relevant to polydrug dynamics and overdose prevention. Beyond identifying basic risk and protective factors, projects can also examine moderators, meaning conditions or characteristics that change how strongly a risk factor operates or for whom a protective factor is most effective. The opportunity also supports research that directly investigates how polydrug use relates to overdose outcomes, which can include studying pathways from co-use to overdose risk and clarifying which combinations, contexts, or trajectories are most dangerous.
A central requirement is that the proposed research be conducted among populations experiencing a disproportionate burden of substance use disorders and overdose. The opportunity highlights a wide range of groups and circumstances that may qualify. These include socio-demographic communities such as non-English speaking populations, tribal populations, rural communities, racial and ethnic minority groups, and sexual and gender minority groups. It also includes people affected by social determinants of health that can elevate vulnerability, such as reduced economic stability, limited educational attainment, limited access to or quality of healthcare (including people who have been historically underserved or are uninsured), limited access to substance use treatment, limited health literacy, and residence in geographically underserved areas. In addition, the CDC emphasizes populations experiencing particular social or physical health conditions linked to heightened risk, including homelessness, mental health conditions, chronic pain, incarceration or recent release from incarceration, disability, and a history of substance use disorders and/or prior overdose. The scope further includes people with adverse childhood experiences as well as individuals with a history of suicidal ideation or suicide attempt, reflecting the program's recognition that overdose risk can intersect with trauma and mental health.
In practical terms, the grant is meant to do two things at once: produce actionable scientific knowledge about polydrug risk and protection, and develop the investigator into an independent, externally funded scientist through structured mentorship. While the notice lists many eligible applicant organization types, the K01 mechanism generally implies an early career investigator is the primary beneficiary, working within an institution or organization that can support the mentored training and research environment. Eligible applicants include various levels of government, public and private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities, nonprofits with or without 501(c)(3) status, and for-profit organizations (including small businesses), among others as clarified in the full announcement.
Key administrative details include an award ceiling of $150,000 and an expected total of three awards. The opportunity was created on November 17, 2022, and the original application deadline was February 9, 2023, with submission required by 11:59 pm Eastern Time on the due date. The program is categorized under health funding activity and is associated with CFDA number 93.136. Overall, this announcement targets new investigators who want to build a mentored research portfolio that advances understanding of why polydrug use develops and escalates, what protects against it, and how it contributes to overdose, particularly in communities carrying the heaviest burden of harm.Apply for RFA CE 23 002
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Grants to Support New Investigators in Conducting Research Related to Understanding Polydrug Use Risk and Protective Factors" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
- This funding opportunity was created on Nov 17, 2022.
- Applicants must submit their applications by Feb 09, 2023 Applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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