Opportunity Information: Apply for RFA DK 17 506
This NIH funding opportunity (RFA-DK-17-506) is a limited competition cooperative agreement (U24) designed to continue and extend the Chronic Renal Insufficiency Cohort (CRIC) Study by supporting its Scientific and Data Coordinating Center (SDCC). CRIC is a long-running, multi-center, prospective observational cohort that began in 2001 and has enrolled about 5,500 adults with chronic kidney disease (CKD). Participants have been followed through annual in-person clinic visits along with interim phone contacts, creating a deep longitudinal dataset to study how CKD develops, progresses, and affects health over time.
The SDCC is positioned as the central hub that keeps the entire CRIC enterprise functioning and scientifically productive. Its responsibilities include leadership and coordination across the study network, study organization and operations, study design and implementation support, and end-to-end data functions such as data collection oversight, quality control, database management, and statistical analysis. In practice, the SDCC role is to ensure the cohort’s follow-up, measurements, and analyses are standardized across sites, that data are reliable and usable for high-impact research, and that the study group can execute the next phase of CRIC efficiently and consistently.
The opportunity is structured around a broader continuation of CRIC in which the Clinical Centers (seven sites) will keep following the already-enrolled participants under a separate funding announcement. Those Clinical Centers will emphasize developing and applying novel methods for clinical assessment of CKD and cardiovascular disease (CVD) risk factors. The SDCC-supported work is expected to integrate these new assessment tools with new analytic approaches so investigators can identify CKD “endophenotypes” (subtypes defined by measurable biological or clinical characteristics), evaluate how those subtypes relate to outcomes like CKD progression and acute kidney injury, and better characterize downstream cardiovascular complications and other sequelae. The larger aim is to generate clearer, more actionable insight into the course and consequences of CKD and its tight relationship with CVD, producing evidence that helps clinicians manage patients more effectively and shaping the design of future clinical trials intended to reduce the burden of kidney and cardiovascular disease.
From an administrative standpoint, this is a discretionary NIH program using the cooperative agreement mechanism, meaning NIH is expected to have substantial involvement in the project’s conduct compared with a typical research grant. The activity category is listed under health (and food and nutrition) and the CFDA number associated with the opportunity is 93.847. The listed award ceiling is $2,250,000, and the original closing date was October 26, 2017 (with the funding opportunity created on August 18, 2017). As a limited competition, it is intended for a narrow applicant pool connected to the continuation of the CRIC coordinating infrastructure rather than an open competition for entirely new coordinating centers.
Eligibility is broad across many domestic organization types, including state, county, and local governments; public and state-controlled and private institutions of higher education; nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities); for-profit organizations (other than small businesses) and small businesses; independent school districts; special district governments; and eligible tribal entities and tribal organizations. The announcement also explicitly calls out additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, foreign participation is explicitly restricted: non-U.S. entities (foreign organizations and foreign institutions) may not apply, non-domestic components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed.
Overall, the grant is essentially about keeping the CRIC Study’s core scientific and data backbone strong so the next project period can deliver more refined measurement, better analytic strategies, and clearer disease subtyping and risk prediction for CKD and related cardiovascular outcomes. The SDCC is expected to lead the study group in achieving these next-phase scientific goals by coordinating the network, maintaining high-quality data systems, and enabling rigorous analyses that translate a large, long-term cohort into findings that can guide clinical management and future interventional research.Apply for RFA DK 17 506
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort Scientific and Data Coordinating Center (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2017-08-18.
- Applicants must submit their applications by 2017-10-26. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,250,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH RFA-DK-17-506 (U24) - CRIC Scientific and Data Coordinating Center (SDCC)
What is the funding opportunity described here?
This is an NIH funding opportunity announcement (RFA-DK-17-506) that uses a cooperative agreement mechanism (U24). It is designed to continue and extend the Chronic Renal Insufficiency Cohort (CRIC) Study by supporting its Scientific and Data Coordinating Center (SDCC).
What is the CRIC Study?
The Chronic Renal Insufficiency Cohort (CRIC) Study is a long-running, multi-center, prospective observational cohort that began in 2001. It has enrolled about 5,500 adults with chronic kidney disease (CKD) and follows participants through annual in-person clinic visits plus interim phone contacts.
What does "prospective observational cohort" mean in this context?
In this opportunity, it refers to tracking already-enrolled participants forward over time without assigning interventions, using repeated measurements (annual clinic visits and interim phone contacts) to understand how CKD develops, progresses, and affects health outcomes.
What is the purpose of funding the SDCC?
The SDCC serves as the central hub that keeps the CRIC enterprise functioning and scientifically productive. The goal is to maintain and strengthen CRIC's core scientific and data backbone so the next project period can produce high-quality, standardized follow-up and analyses across the study network.
What are the main responsibilities of the SDCC under this opportunity?
Based on the description provided, the SDCC responsibilities include:
- Leadership and coordination across the CRIC study network
- Study organization and operations
- Study design and implementation support
- Oversight of data collection
- Quality control
- Database management
- Statistical analysis
- Ensuring standardized measurements and follow-up across sites
- Ensuring data are reliable and usable for high-impact research
How does the SDCC fit with the Clinical Centers?
The broader continuation of CRIC includes seven Clinical Centers that will continue following the already-enrolled participants under a separate funding announcement. The SDCC-supported work is expected to coordinate and integrate network-wide operations and data functions so that the Clinical Centers' efforts can be harmonized and analyzed consistently.
How many Clinical Centers are involved?
The opportunity description references seven Clinical Centers (seven sites) that will continue participant follow-up under a separate funding announcement.
What is meant by "limited competition" for this grant?
This is a limited competition, meaning it is intended for a narrow applicant pool connected to the continuation of the CRIC coordinating infrastructure rather than an open competition for entirely new coordinating centers.
What does the cooperative agreement mechanism (U24) imply?
Because this is a cooperative agreement, NIH is expected to have substantial involvement in the project's conduct compared with a typical research grant. The opportunity is described as a discretionary NIH program using this mechanism.
What scientific areas will this next phase of CRIC emphasize?
The continuation described here emphasizes developing and applying novel methods for clinical assessment of CKD and cardiovascular disease (CVD) risk factors at the Clinical Centers, and integrating these tools with new analytic approaches through the SDCC.
What kinds of research questions is this SDCC work expected to enable?
The SDCC-supported work is expected to help investigators:
- Identify CKD "endophenotypes" (subtypes defined by measurable biological or clinical characteristics)
- Evaluate how CKD subtypes relate to outcomes such as CKD progression and acute kidney injury
- Better characterize downstream cardiovascular complications and other sequelae
What are CKD "endophenotypes" as used in this announcement?
In this context, endophenotypes are CKD subtypes defined by measurable biological or clinical characteristics. The aim is to use improved measurement and analytic strategies to define these subtypes and link them to clinical outcomes.
Why is cardiovascular disease (CVD) a focus in a CKD cohort?
The opportunity highlights the tight relationship between CKD and CVD. A major aim is to characterize cardiovascular complications and other consequences that occur downstream of CKD and to produce evidence relevant to both kidney and cardiovascular outcomes.
How will this funding help clinicians and future research?
The described aim is to generate clearer, more actionable insight into the course and consequences of CKD and its relationship with CVD. The intended impact includes evidence that helps clinicians manage patients more effectively and information that shapes the design of future clinical trials intended to reduce the burden of kidney and cardiovascular disease.
What kind of dataset does CRIC provide?
CRIC is described as having deep longitudinal data created through annual in-person clinic visits and interim phone contacts over many years. This structure supports long-term analyses of CKD progression and related outcomes.
What does the SDCC do to ensure data are usable across multiple sites?
The SDCC is described as ensuring that follow-up, measurements, and analyses are standardized across sites, and that data collection oversight, quality control, database management, and statistical analysis are conducted in a way that produces reliable, high-quality data for research.
What is the activity code for this opportunity?
The activity is a cooperative agreement with an activity code of U24.
What is the CFDA number associated with this opportunity?
The CFDA number listed for the opportunity is 93.847.
What is the listed award ceiling?
The listed award ceiling is $2,250,000.
When was this funding opportunity created and when did it close?
The opportunity was created on August 18, 2017, and the original closing date was October 26, 2017.
What general subject area does the program fall under?
The activity category is listed under health (and food and nutrition).
Who is eligible to apply?
Eligibility is described as broad across many domestic organization types, including:
- State, county, and local governments
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations (501(c)(3) and non-501(c)(3))
- For-profit organizations (other than small businesses) and small businesses
- Independent school districts
- Special district governments
- Eligible tribal entities and tribal organizations
- U.S. territories or possessions
- Eligible federal agencies
- Regional organizations
- Faith-based or community-based organizations
Are minority-serving institutions specifically mentioned as eligible?
Yes. The announcement explicitly calls out eligibility for several categories, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are foreign organizations allowed to apply?
No. Foreign participation is explicitly restricted. Non-U.S. entities (foreign organizations and foreign institutions) may not apply.
Can a U.S. organization include a non-domestic component on the application?
No. Non-domestic components of U.S. organizations are described as not eligible.
Are foreign components (as defined by NIH policy) allowed?
No. The opportunity states that foreign components, as defined by NIH policy, are not allowed.
Is this opportunity intended to start a brand-new cohort?
No. The description emphasizes continuation and extension of an existing cohort (CRIC), including ongoing follow-up of already-enrolled participants, rather than initiating a new cohort from scratch.
Does this opportunity fund the Clinical Centers directly?
The description indicates that the seven Clinical Centers will be funded under a separate funding announcement. This specific opportunity focuses on supporting the SDCC.
What is the overall goal of the SDCC in the next phase of CRIC?
The SDCC is expected to lead and enable the study group to achieve next-phase scientific goals by coordinating the network, maintaining high-quality data systems, integrating new assessment tools with analytic approaches, and enabling rigorous analyses that translate the cohort into findings relevant to CKD and cardiovascular outcomes.
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| Funding Opportunity |
|---|
| Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Clinical Centers (U01) Apply for RFA DK 17 505 Funding Number: RFA DK 17 505 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $650,000 |
| Developmental Centers for Interdisciplinary Research in Benign Urology (P20 - Clinical Trials Not Allowed) Apply for RFA DK 17 033 Funding Number: RFA DK 17 033 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Investigator-Initiated Clinical Trials Targeting Diseases within the Mission of NIDDK (R01-Clinical Trial Required) Apply for PA 18 330 Funding Number: PA 18 330 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Program Projects (P01 Clinical Trial Optional) Apply for PAR 18 012 Funding Number: PAR 18 012 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $6,250,000 |
| Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01 Clinical Trial Optional) Apply for PAR 18 042 Funding Number: PAR 18 042 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01 Clinical Trial Optional) Apply for PAR 18 051 Funding Number: PAR 18 051 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21 Clinical Trial Optional) Apply for PA 18 052 Funding Number: PA 18 052 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Pilot and Feasibility Clinical Research Grants in Kidney Diseases (R21 Clinical Trial Optional) Apply for PAR 18 100 Funding Number: PAR 18 100 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Pilot and Feasibility Clinical and Translational Research Studies in Digestive Diseases and Nutrition (R21 Clinical Trial Optional) Apply for PA 18 099 Funding Number: PA 18 099 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Pilot and Feasibility Clinical Research Grants in Urologic Disorders (R21 Clinical Trial Optional) Apply for PAR 18 101 Funding Number: PAR 18 101 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Small Grants for New Investigators to Promote Diversity in Health-Related Research (R21 Clinical Trial Optional) Apply for PAR 18 102 Funding Number: PAR 18 102 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $125,000 |
| Limited Competition: Small Grant Program for NIDDK K01/K08/K23 Recipients (R03 Clinical Trial Optional) Apply for PAR 18 103 Funding Number: PAR 18 103 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $50,000 |
| Addressing Health Disparities in NIDDK Diseases (R01 - Clinical Trial Not Allowed) Apply for PA 18 412 Funding Number: PA 18 412 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Ancillary Studies to Identify Behavioral and/or Psychological Phenotypes Contributing to Obesity (R01 Clinical Trial Optional) Apply for PAR 18 105 Funding Number: PAR 18 105 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R18 Clinical Trial Required) Apply for PAR 18 106 Funding Number: PAR 18 106 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Planning Grants for Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R34 Clinical Trial Required) Apply for PAR 18 107 Funding Number: PAR 18 107 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $150,000 |
| Elucidating HIV and HIV-treatment Associated Metabolic/Endocrine Dysfunction (R01 Clinical Trial Optional) Apply for RFA DK 17 036 Funding Number: RFA DK 17 036 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Pilot and Feasibility Therapeutic Clinical Trials in Diabetes, and Endocrine and Metabolic Diseases (R21- Clinical Trial Required) Apply for PA 18 405 Funding Number: PA 18 405 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| NIDDK Exploratory Clinical Trials for Small Business (R44 Clinical Trial Required) Apply for PAR 18 108 Funding Number: PAR 18 108 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional) Apply for PAR 18 423 Funding Number: PAR 18 423 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $225,000 |
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