Opportunity Information: Apply for 80JSC018N0001 FLAGSHIP
Appendix A, titled "NASA Research and Technology Development to Support Crew Health and Performance in Space Exploration Missions," is a solicited research area under NASA's broader Human Exploration Research Opportunities (HERO) NASA Research Announcement (NRA) number 80JSC018N0001. Managed through NASA's Johnson Space Center and aligned with the Human Research Program (HRP), this opportunity is focused on applied research and technology development that directly supports HRP goals for keeping astronauts healthy, capable, and mission-ready during long-duration exploration missions. The intent is to fund work that improves understanding of key human health and performance risks in space and advances practical countermeasures, tools, or evidence that NASA can use in planning and conducting future exploration missions.
The solicitation highlights several specific research focus areas. One major emphasis is the risk of combined or "synergistic" effects from radiation exposure, psychological or operational stress, and altered gravity (such as microgravity or partial gravity) on behavioral health and performance. This topic reflects NASA's interest in how multiple spaceflight stressors interact rather than treating each risk in isolation, with outcomes relevant to cognition, mood, team functioning, operational performance, and overall mission safety. The opportunity also includes a Virtual NASA Specialized Center of Research (VNSCOR) element, indicating an interest in coordinated, center-like research efforts that can integrate expertise across disciplines and institutions in a virtual collaboration model. Another component is space radiobiology tissue sharing, encouraging proposals that make use of archived tissue samples or samples from ongoing experiments, which can accelerate discoveries, improve reproducibility, and maximize the scientific return from existing biological materials. In addition, NASA specifically calls for research on how radiation dose-rate affects space radiation health risks, a topic important for refining risk models and understanding how different exposure patterns may change biological outcomes and long-term health consequences.
From an administrative and funding standpoint, this is a discretionary federal funding opportunity with multiple possible award instruments, including cooperative agreements, grants, and procurement contracts. The CFDA listing is 43.003. The announcement anticipates approximately five awards, with an award ceiling of $1,800,000. Eligibility is broadly open to all categories of U.S. institutions, meaning universities, nonprofits, for-profits, and government-affiliated entities can apply, subject to any specific clarifications in the full solicitation. Principal Investigators are allowed to form collaborations with universities, federal laboratories, industry partners, and state or local government labs. In collaborative arrangements, the submitting organization is expected to take responsibility for project administration and execution according to the management approach described in the proposal. NASA also notes its general policy for working with non-U.S. organizations: such partnerships are typically allowed on a cooperative basis with no exchange of funds, meaning international collaborators can contribute expertise or resources, but NASA funding generally does not flow to non-U.S. entities.
The application process follows a two-step proposal structure. Step-1 proposals were due September 5, 2018, and only applicants invited forward would submit Step-2 proposals, which were due November 30, 2018. NASA also scheduled a virtual pre-proposers conference for August 15, 2018, intended to help potential applicants understand objectives, expectations, and submission logistics, with details posted through NSPIRES, NASA's proposal submission and review system. The full Appendix A text and associated documents were made available online as part of the HERO NRA, and applicants were directed to the solicitation package for official contacts, requirements, and evaluation details.Apply for 80JSC018N0001 FLAGSHIP
- The National Aeronautics and Space Administration, NASA Johnson Space Center in the science and technology and other research and development sector is offering a public funding opportunity titled "Appendix A: NASA Research and Technology Development to Support Crew Health and Performance in Space Exploration Missions" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 43.003.
- This funding opportunity was created on Aug 01, 2018.
- Applicants must submit their applications by Sep 05, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,800,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is Appendix A, titled "NASA Research and Technology Development to Support Crew Health and Performance in Space Exploration Missions," which is a solicited research area under NASA's Human Exploration Research Opportunities (HERO) NASA Research Announcement (NRA) number 80JSC018N0001.
Which NASA organization manages this opportunity?
The opportunity is managed through NASA's Johnson Space Center and is aligned with NASA's Human Research Program (HRP).
What is the overall purpose of this solicitation?
The intent is to fund applied research and technology development that supports HRP goals for keeping astronauts healthy, capable, and mission-ready during long-duration exploration missions. The focus is on improving understanding of key human health and performance risks in space and advancing practical countermeasures, tools, or evidence that NASA can use in planning and conducting future exploration missions.
What types of work is NASA looking to fund?
NASA is seeking applied research and technology development that directly supports HRP goals. The solicitation emphasizes work that advances usable countermeasures, tools, and evidence relevant to astronaut health, performance, and mission readiness during long-duration exploration missions.
What are the main research focus areas highlighted in the solicitation?
The solicitation highlights multiple focus areas, including: (1) combined or "synergistic" effects from radiation exposure, psychological or operational stress, and altered gravity on behavioral health and performance; (2) a Virtual NASA Specialized Center of Research (VNSCOR) element supporting coordinated, virtual, center-like research efforts; (3) space radiobiology tissue sharing using archived tissues or samples from ongoing experiments; and (4) research on how radiation dose-rate affects space radiation health risks.
What does NASA mean by "synergistic effects" in this solicitation?
In this context, "synergistic effects" refers to how multiple spaceflight stressors (radiation exposure, psychological or operational stress, and altered gravity such as microgravity or partial gravity) may interact, rather than being studied as isolated risks.
What outcomes are relevant for the synergistic effects topic?
The solicitation describes outcomes relevant to behavioral health and performance, including cognition, mood, team functioning, operational performance, and overall mission safety.
What is the VNSCOR element?
VNSCOR stands for Virtual NASA Specialized Center of Research. The solicitation indicates interest in coordinated, center-like research efforts that integrate expertise across disciplines and institutions using a virtual collaboration model.
What is meant by "space radiobiology tissue sharing"?
This refers to proposals that make use of archived tissue samples or samples from ongoing experiments. NASA highlights this approach as a way to accelerate discoveries, improve reproducibility, and maximize the scientific return from existing biological materials.
What is the focus on radiation dose-rate?
NASA specifically calls for research on how radiation dose-rate affects space radiation health risks. This is described as important for refining risk models and understanding how different exposure patterns may change biological outcomes and long-term health consequences.
Is this a discretionary federal funding opportunity?
Yes. The opportunity is described as a discretionary federal funding opportunity.
What award instruments may be used under this opportunity?
The announcement notes multiple possible award instruments, including cooperative agreements, grants, and procurement contracts.
What is the CFDA number for this opportunity?
The CFDA listing for this opportunity is 43.003.
How many awards does NASA anticipate making?
The announcement anticipates approximately five awards.
What is the maximum (ceiling) award amount?
The award ceiling is $1,800,000.
Who is eligible to apply?
Eligibility is broadly open to all categories of U.S. institutions. This includes universities, nonprofits, for-profits, and government-affiliated entities, subject to any specific clarifications in the full solicitation.
Can the Principal Investigator collaborate with other organizations?
Yes. Principal Investigators are allowed to form collaborations with universities, federal laboratories, industry partners, and state or local government labs.
In a collaboration, who is responsible for project administration?
In collaborative arrangements, the submitting organization is expected to take responsibility for project administration and execution according to the management approach described in the proposal.
Are non-U.S. organizations allowed to participate?
NASA notes a general policy that partnerships with non-U.S. organizations are typically allowed on a cooperative basis with no exchange of funds. International collaborators may contribute expertise or resources, but NASA funding generally does not flow to non-U.S. entities.
What is the proposal submission structure?
The application process follows a two-step proposal structure. Step-1 proposals were required first, and only applicants invited forward would submit Step-2 proposals.
When were Step-1 proposals due?
Step-1 proposals were due September 5, 2018.
When were Step-2 proposals due?
Step-2 proposals were due November 30, 2018, and only for applicants invited forward after Step 1.
Was there a pre-proposers conference?
Yes. NASA scheduled a virtual pre-proposers conference for August 15, 2018.
What was the purpose of the pre-proposers conference?
The virtual pre-proposers conference was intended to help potential applicants understand objectives, expectations, and submission logistics.
Where were conference details posted?
Details were posted through NSPIRES, NASA's proposal submission and review system.
Where can applicants find the full Appendix A text and official requirements?
The full Appendix A text and associated documents were made available online as part of the HERO NRA. Applicants were directed to the solicitation package for official contacts, requirements, and evaluation details.
What is NSPIRES?
NSPIRES is NASA's proposal submission and review system, and it is referenced as the location where details (such as for the virtual pre-proposers conference) were posted.
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